At the University of Antwerp, ER3 will elucidate the pathways, kinetics, and biotransformation products of the human metabolism of A-TEAM's target chemicals, focusing on those chemicals (e.g. EBFRs and OPEs) for which metabolism is suspected to be extensive. ER3 will: (a) develop in vitro assays to characterize the human metabolism of selected chemicals; (b) use substrate-depletion approach to estimate the intrinsic in vitro clearance and ultimately the in vivo clearance of selected EBFRs and OPEs; and (c) screen in vitro formation of EBFR and OPE metabolites to develop biomarkers of exposure for biomonitoring. ER3 will identify suitable biomarkers of exposure for contaminants for which no or limited knowledge regarding their biotransformation currently exists. The work of ER3 is closely complementary to that of ESRs 5, 6, 7, and 8. Synergies also exist with ESRs 2 & 11.
Contact: Prof. Adrian Covaci, University of Antwerp
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