At Stockholm University and with strong links to the research of ESRs 3, 4 and 11, ESR7 will synthesise our knowledge of human exposure to these contaminants as well as conduct PK modelling to relate external and internal exposure. Human exposure to these emerging contaminants has changed rapidly over recent years necessitating a dynamic understanding of exposure. Present day external and internal exposure estimates provided by ESR3 and ESR4 will be used for model evaluation. However, as internal and external exposures are unlikely to be at "steady-state", an unsteady-state (time-varying) PK modelling approach will be used to describe how exposures have changed over time. For some selected substances (e.g. PFOS) exposures are decreasing, but for others (e.g. EBFRs and some PFAS) exposures are increasing. Links with ESR11 will help better constrain the PK model for PFOS exposure.

Contact: Prof. Ian Cousins, Stockholm University

Email: [email protected]