Advanced Tools For Exposure
Assessment and Biomonitoring
ESR9 How bioaccessible are contaminants present in air, dust and diet?
At the University of Reading, ESR10 will use a colon extended physiologically based extraction test (CEPBET) to examine the extent to which selected exemplars of A-TEAM's target contaminants present in dust and diet are available in the human gastrointestinal tract for uptake across biological membranes (bioaccessible). The influence on bioaccessibility of a variety of factors will be investigated including: contaminant concentration and physicochemical properties; properties of dust like particle size and organic carbon content or diet like lipid content; the quantity of dust/food ingested; and physiological factors such as fed and fasted state. ESR9 will also explore emerging approaches to examining the uptake of contaminants from airborne particles into synthetic lung fluids.
Contact: Prof. Chris Collins, University of Reading